Pair Name	Ursolic acid, Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Autophagy
Gene Regulation	Down-regulation	Expression	MCL1	hsa4170
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
	SMMC-7721	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0534
	Huh-7	Adult hepatocellular carcinoma	Homo sapiens (Human)	CVCL_0336
	H22	Hepatocellular carcinoma	Mus musculus (Mouse)	CVCL_H613
In Vivo Model	To assess the inhibitory effect of different drugs on mouse liver cancer xenografts, six experimental groups of mice were  randomly  set up: (1) Control (saline), (2) UA (4 mg/kg), (3) Sora (4 mg/kg), (4) UA + Sora (UA 4 mg/kg, Sora 4 mg/kg), (5) US NPs (UA 4 mg/kg, Sora 4 mg/kg), (6) US NPs + rapamycin (UA 4 mg/kg, Sora 4 mg/kg), 6 mice in each group.
Result	The carrier-free US NPs provide new strategies for HCC treatment and new ideas for the development of novel nano-drug delivery systems containing UA and Sora.

Pair Name	Ursolic acid, Sorafenib
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Biological Phenomena	Induction-->Ferroptosis
Gene Regulation	Up-regulation	Expression	BIM	hsa10018
	Up-regulation	Expression	CASP3	hsa836
	Up-regulation	Expression	CASP8	hsa841
	Up-regulation	Expression	CASP9	hsa842
	Down-regulation	Expression	MCL1	hsa4170
	Up-regulation	Expression	PARP1	hsa142
	Up-regulation	Expression	ROS1	hsa6098
	Down-regulation	Expression	SLC7A11	hsa23657
In Vitro Model	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
	AGS	Gastric adenocarcinoma	Homo sapiens (Human)	CVCL_0139
In Vivo Model	HCT 116 cells (3×10⁶), HCT116 Vector cells (3×10⁶), HCT116 Mcl-1 overexpression cells (3×10⁶) and HCT116 SLC7A11 overexpression cells (3×10⁶) suspended in 0.2 ml of PBS were subcutaneously inoculated into the right flank of each mouse.
Result	These results suggest that the synergistic antitumor effects of sorafenib combined with ursolic acid may involve the induction of Mcl-1-related apoptosis and SLC7A11-dependent ferroptosis. Our findings may offer a novel effective therapeutic strategy for tumor treatment.